Kunze's model for estimating renal clearance

Kunze et al., 2014

Renal clearance is one of the major contributing mechanisms for removing a drug from the body. Though lots of drugs are primarily cleared by metabolic routes, like the liver, others, such as antibiotics and antivirals, are primarily renally cleared. This paper uses a simplification (and a popular one) in simplifying the kidney's activity down to three steps in the process of passing drugs from the bloodstream to urine - filtration, secretion, and reabsorption.

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