J Tyler Smith

Developed and provided analytical tools alongside an array of microphysiological devices ("chips") for use in long-term (up to 1 week) in-vitro drug metabolism and pharmacokinetic studies.

Key contributions:

• Developed an analysis plan to evaluate analytical models of compound depletion, including via metabolism and chip-component binding, across several chip design iterations.
• Comparison of chip-derived metabolism estimates to known in-vivo properties of drugs across a large span of small molecules, including acid and basic compounds and lipophilic and lipophobic compounds.
• Worked with a third party developer to build tools for bench pharmacologists to use with our chips to get pharmacokinetic parameter estimates.

Biomathematics researcher under advisor Dr. Libin Rong studying a variety of ODE and DDE models of HIV infection using Matlab, R, and Monolix.

Further, teaching assistant and primary instructor for courses in the mathematics department, including the calculus sequence, elementary differential equations, and mathematics for liberal arts majors.

Data analyst and bench researcher for two collaborating labs in neuroanatomy and physiology (Drs. Marilyn Duncan and Karyn Esser) studying various aspects of circadian rhythms. Studies included mouse, hamster, and human studies related to Alzheimer's disease and metabolic disorders.

Specifical contributions were in bringing circular statistical techniques and functional data analysis into the workflows of the two labs.

Graduate assistant statistical consultant for the Applied Statistics Lab, housed within the statistics and biostatistics departments. Projects included structured meetings with clients, often in the early investigatory (pre-grant) stages as a wider campus service to faculty and graduate students.